In addition, researchers discovered that exosomes obtained from mesenchymal stem cells produced from human-induced pluripotent stem cells (HiMSC-Exo) improved the survival of heart muscle cells and alleviated myocardial infarction caused by severe acute pancreatitis (SAP) through the activation of the Akt/Nrf2/HO-1 signaling pathway. Here, NFE2L2 is linked to myocardial infarction.