KLRK1 and osteosarcoma: Further investigations have revealed that the activation of IL-15 significantly augments the NK cell-mediated eradication of chemotherapy-resistant osteosarcoma cells, an effect dependent on the DNAM-1 and NKG2D pathways, indicating the specificity of NK cells in recognizing and eliminating osteosarcoma cells (Buddingh et al., 2011).