IL34 and osteosarcoma: Ségaliny et al. demonstrated that IL-34, with its expression upregulated in osteosarcoma, markedly enhances angiogenesis and recruits M2-type macrophages, a circumstance associated with enhanced M2-TAM infiltration, thereby emphasizing the role of M2-TAMs in the advancement of osteosarcoma (Segaliny et al., 2015).