Nirala et al. elucidated that upregulation of microRNA 17/20a by the MYC gene leads to decreased levels of macrophage colony-stimulating factor 1 (CSF1), culminating in a reduced macrophage population within the TME, potentially influencing osteosarcoma progression and metastasis (Nirala et al., 2023). Here, MYC is linked to osteosarcoma.