Li et al.’s study on osteosarcoma-derived microparticles (T-MPs) indicated initiation of macrophage polarization towards the M2 phenotype through the TBK1-STAT6 pathway, and manipulation of osteosarcoma cell conduct via the CCL18/STAT3 signaling pathway, thereby enhancing migration ability and chemotherapeutic resistance (Li et al., 2024). Here, TBK1 is linked to osteosarcoma.