Membrane-bound CX3CL1 is located on the cell membrane and mainly acts as an adhesion molecule to enhance cell adhesion, while soluble CX3CL1 is mainly released into the stroma, and attracts CX3CR1-expressing cytotoxic T cells, monocytes, and NK cells to migrate towards the tumor, achieving an anti-tumor effect. The gene discussed is CX3CR1; the disease is neoplasm.