To ascertain the specificity of the heightened expression of RHBDF2 and TNFRSF10B in AD, our study extended to examining the expression profiles of these genes in various other neurodegenerative disorders, including Parkinson’s disease (PD), frontotemporal dementia (FTD), dementia with Lewy bodies (DLB), and Huntington’s disease (HD). The gene discussed is RHBDF2; the disease is frontotemporal dementia.