RHBDF2 and Alzheimer disease: To elucidate the link between RHBDF2 and TNFRSF10B with infiltrating immune cells in AD, we utilized CIBERSORT (Supplementary Figure S4) and xCell (Supplementary Figure S5) algorithms to assess immune cell profiles across various cohorts: AD patients versus controls, high versus low RHBDF2 expression, and high versus low TNFRSF10B expression.