Specifically, CD8+ T cells and plasma cells exhibited decreased proportions in the AD, high RHBDF2 expression, and high TNFRSF10B expression groups as per CIBERSORT analysis, while neutrophils, M1 macrophages, and monocytes showed increased proportions in these groups (Figures 3C-E). The gene discussed is RHBDF2; the disease is Alzheimer disease.