GeneMANIA analysis revealed that RHBDF2 is involved in epidermal growth factor receptor and ERBB signaling pathways, interacting with RHBDF1, ADAM17, and EGF (Supplementary Figure S2, Supplementary Table S2), suggesting RHBDF2’s potential involvement in multiple immune response pathways related to AD. The gene discussed is EGF; the disease is Alzheimer disease.