TNFRSF10B, on the other hand, is mainly involved in extrinsic apoptosis signaling pathways, interacting with TNFSF10, FAS, FADD, and CASP8 to form the death-inducing signaling complex (Supplementary Figure S2, Supplementary Table S2), potentially exacerbating immune cascade reactions in AD through inducing cell apoptosis. This evidence concerns the gene CASP8 and Alzheimer disease.