Specifically, CD8+ T cells and plasma cells exhibited decreased proportions in the AD, high RHBDF2 expression, and high TNFRSF10B expression groups as per CIBERSORT analysis, while neutrophils, M1 macrophages, and monocytes showed increased proportions in these groups (Figures 3C-E). This evidence concerns the gene TNFRSF10B and Alzheimer disease.