CA9 and neoplasm: A pH-responsive calcium carbonate nanoparticle (CaCO3/CAI@Liposome, CCL) was prepared by loading calcium carbonate nanoparticles with CAIX inhibitors (CAI) and coating with liposomes, which can accurately regulate the content of Ca2+ and pH in and out of tumor cells to promote DCs maturation and macrophage polarization towards the anti-tumor M1 type (69).