By downregulating vascular endothelial cell adhesion molecule-1 and matrix metalloproteinase-9 (MMP-9) and upregulating PKG and endothelial nitric oxide synthase (eNOS), FGE decreased blood pressure in rats with pulmonary hypertension induced by monocrotaline (181). The gene discussed is MMP9; the disease is pulmonary arterial hypertension.