LBP and glioblastoma: Research has shown that in GBM, metabolites of gut microbiota such as 5-hydroxytryptamine, Norepinephrine, Glutamine, and lipopolysaccharide binding proteins (LBP) can promote the proliferation and migration of GBM cells, while dopamine, lipopolysaccharides (LPS) play the opposite role (14–16) (Figure 1).