Recent studies have revealed the involvement of RBM15 in cellular biological behaviors such as proliferation, invasion, migration, and apoptosis in various cancers, like acute megakaryocytic leukemia (36), colorectal cancer (37), ovarian cancer (38), laryngeal squamous cell carcinoma (25) and osteosarcoma (39). Here, RBM15 is linked to acute megakaryoblastic leukemia.