Studies have shown that the protein expression of TRPA1 channel significantly increased in AD transgenic mice, mainly in astrocytes of the hippocampus, and TRPA1 could be involved in the pathogenesis of AD through multiple pathways (Lee et al., 2016; Bosson et al., 2017; Paumier et al., 2022). The gene discussed is TRPA1; the disease is Alzheimer disease.