C4B and Alzheimer disease: To validate unbiased study results on RNA-Seq, PCA analyses providing variances of the dataset (Supplementary Figures S6, S7), GSEA on AD (Supplementary Figure S8) and CH (Supplementary Figure S9) along with enrichment analyses via G-profiler (Supplementary Figures S11, S12), Hierarchical Clustering (Supplementary Figure S13), and histological detection of vascular proteins as compared to RNA-Seq dataset are conducted as provided in Supplementary Figure S14.