LDLRAP1 and Alzheimer disease: Consistent with the heatmap of RNA-Seq (Figure 1), we found that LDLRAP1 was significantly elevated in the caudate nucleus with AD (p = 0.01) as compared to that of age-matched controls, while tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4) was only elevated in the caudate nucleus with CH (p = 0.02).