APP and autosomal dominant disease: Mutations in the amyloid precursor protein (APP) and presenilin genes (Boutajangout et al., 2004), both linked to aβ metabolism cause familial AD, a very rare autosomal dominant disease with early onset (Catania et al., 2022; Kalfon et al., 2022; Pagnon de la Vega et al., 2022; Hebestreit et al., 2023; Kriebs, 2023; Lardelli et al., 2023; Li et al., 2023).