Research is ongoing into the genes that predispose to the development of MASLD; however, the single nucleotide polymorphism rs738409 of the human patatin-like phospholipase domain-containing-3 (PNPLA3) gene appears to play a significant role in all populations and also accounts for the interethnic variability in disease susceptibility [17, 18]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.