In humans with AD, genetic links have been made to Adaptor Related Protein Complex 2 (AP2) and Phosphatidylinositol Binding Clathrin Assembly Protein (PICALM) (Raj et al., 2018; Azarnia et al., 2019) and many proteins involved in CME have reported changes at the RNA and protein level over a wide variety of brain regions (Yao et al., 1999, 2000, 2003; Cao et al., 2010; Jaye et al., 2024). Here, PICALM is linked to Alzheimer disease.