ITSN1 and Alzheimer disease: It is interesting that in the HP of 9-month-old 5xFAD mice we see the same pattern seen in human post-mortem AD HP; a trending increase in baseline level of ITSN1-L in WT female mice compared to WT males and a decrease of ITSN1-L in HP of 5xFAD females compared to WT females.