Here, we examined, in both males and females, levels of CME proteins that have been previously implicated in human AD: Intersectin 1 (ITSN1) (Wilmot et al., 2008; Malakooti, 2019), Clathrin Light Chain A (CLTA) (Nakamura et al., 1994), PICALM (Raj et al., 2018; Azarnia et al., 2019; Alsaqati et al., 2023), FCH and Mu Domain Containing Endocytic Adaptor 1 (FCHO1) (Teerlink et al., 2021), Adaptor Related Protein Complex 2 (AP2) Subunit Alpha 1 (AP2A1) (Yao et al., 2000; Srinivasan et al., 2022), and Dynamin 2 (DNM2) (Aidaralieva et al., 2008; Kamagata et al., 2009; Du et al., 2021). This evidence concerns the gene PICALM and Alzheimer disease.