As age is the highest risk factor for AD (Guerreiro and Bras, 2015), CME proteins increase with age (Alsaqati et al., 2018), and ITSN1 itself is increased with age in as shown in a Down Syndrome (DS) mouse model (Ahmed et al., 2017), there is a high likelihood that age-related changes may play an important role in ITSN1 function and dysfunction in AD. Here, ITSN1 is linked to Down syndrome.