As ITSN1 is involved in neurodevelopment (Jakob et al., 2017) and AD pathology does not appear until adulthood, we examined ITSN1 levels between 5xFAD and WT at 1-, 3-, 6-, and 9-months in both males and females (Figures 3, 4). The gene discussed is ITSN1; the disease is Alzheimer disease.