Previously, PICALM was shown to have differences in AD between isoforms (Ando et al., 2013, 2016; Alsaqati et al., 2023), so we evaluated the effect of AD on both isoforms 1,2 (65–75 kDa), and isoform 4 (50 kDa). The gene discussed is PICALM; the disease is Alzheimer disease.