Cluster C1 (40% prevalence) encompassed older patients, fewer males, fewer individuals from non-white ethnicity, more comorbidities (hypertension, coronary, chronic heart failure, diabetes, kidney, pre-existing respiratory conditions, etc.), higher creatinine and pro-natriuretic peptide (pro-BNP), but lower inflammatory markers (CRP, alanine). The gene discussed is CRP; the disease is hypertensive disorder.