Further improving the CD5-targeting efficacy, Mamonkin M et al.‘s study [12] showed that CD5-targeted CAR-T cells with the CD28 costimulatory domain effectively reduced CD5 surface expression, diminished autophagy triggered by self-targeting, and exhibited significant cytotoxicity in vitro and in vivo in a T-ALL model. Here, CD5 is linked to acute lymphoblastic leukemia.