Zheng et al. [46] reported a significant increase in CCR8 expression in an ATLL model and showed that the CAR-T cells targeting CCR8 that they developed exhibited potent antitumor activity that could be achieved without affecting normal T-cell expansion and without impairing the immunosuppressive function of Treg cells to prolong the survival of tumor-bearing mice. The gene discussed is CCR8; the disease is neoplasm.