Mechanistic studies with 13(S)-hydroxyoctadecadienoic acid (13S-HODE) and (S)-2-hydroxybutanoate (S-2HB) revealed elevated β2m protein levels, increased cell surface β2m expression, and induced IL-2 secretion from T cell hybridoma co-cultures, consistent with enhanced MHC-I cell surface presentation on colon cancer cells [82]. This evidence concerns the gene B2M and colonic neoplasm.