Because of the high myeloid cell composition within Tumor KC3 neighborhood, we further dissected the myeloid cells into several subsets, including AXL + SIGLEC6 + dendritic cells (ASDCs), CD1C + dendritic cells (CD1Cs), CLEC9A + dendritic cells (CLEC9As), Langerhans cells (LCs), macrophages (Macs), myeloid-derived suppressor cells (MDSCs), and plasmacytoid dendritic cells (PDCs), and compared their differential spatial affinity with tumor KCs and T cells (Additional file 1: Fig. S10d). This evidence concerns the gene CD1C and neoplasm.