Enrichment analysis for DEGs [43–45] of distinct tumor KC neighborhood revealed significantly enriched signatures for squamous and epithelial senescence genes in Tumor KC1, stress and epithelial-to-mesenchymal transition (EMT) genes in Tumor KC2, and cell cycle and interferon genes in Tumor KC3 (Additional file 1: Fig. S9b-d). The gene discussed is CALCA; the disease is neoplasm.