CD274 and neoplasm: For example, while we observed high anti-tumor type II Interferon (IFN-II) signaling in T cells that are proximal to tumor KCs, Programmed cell death ligand 1 (PD-L1) and Programmed cell death ligand 2 (PD-L2) signaling are also high in tumor KC-proximal T cells compared to those distal T cells, which agreed with the immunosuppressive microenvironment around the tumor defined by the original publication [21].