VIM and neoplasm: Evidence supports that the expression of vimentin leads to the conversion of benign tumor cells into metastatic cells with an increased invasive phenotype [14, 15], whereas vimentin deficiency results in various defects in EMT-promoting cellular architectures, including impaired microtubule polarization, failure to form actin stress fibers, and defective focal adhesion maturation, which lead to reduced mechanical strength [16].