VIM and viral infectious disease: However, in HeLa_VIMKO cells, internal integrin β1 staining was not visible under any condition (Fig. 5B, bottom panels), while reintroducing vimentin into HeLa_VIMKO cells through viral infection led to the revival of internal β1 staining (Fig. 5C, yellow arrows), suggesting that vimentin may play a role in keeping internalized integrin β1.