Subsequently, we found that circSORBS1 acts as a miR-6779-5p sponge and indirectly inhibits RUFY3 mRNA degradation, while also directly binding to RUFY3 mRNA and enhancing mRNA stability, which in turn increases RUFY3 protein expression, activates the YWHAE/BAD/BCL2 apoptosis signalling pathway, and inhibits lung cancer progression. Here, YWHAE is linked to lung carcinoma.