In particular, several key sphingolipids (e.g., sphingosine-1-phosphate (S1P), ceremide) and related enzymes (e.g., sphingosine kinases (SphK1/2), ceramide kinases (Cerk)) were found to play crucial roles in lung cancer etiology by disrupting universe cellular processes, regulating downstream signaling pathways, and affecting tumor microenvironment [32, 35–39]. The gene discussed is SPHK1; the disease is lung cancer.