Kang et al. explored the association between BDNF methylation, depression, and suicide; they found that a higher BDNF-promoting methylation status was significantly associated with a history of prior suicide attempts, suicidal ideation during treatment, suicidal ideation at final evaluation, higher suicidal ideation scores, and adverse outcomes of suicidal ideation treatment [61]. The gene discussed is BDNF; the disease is major depressive disorder.