Although PIM1 mutations identified in our case are variants of uncertain significance (VUS), three out of the four mutations (c.87G > C, c.68C > T, and c.286G > C) have been reported multiple times in DLBCL [16–18] respectively; the other PIM1 mutation (c.113A > T) has not been reported to our knowledge. Here, PIM1 is linked to diffuse large B-cell lymphoma.