PALB2 and breast carcinoma: Although the PALB2 c.509_510del and c.172_175del were identified as founder or hotspot mutations in European populations (Rogoża-Janiszewska et al. 2020), and PALB2 c.2968G>T was found to be a hotspot mutation in women with breast cancer from Malaysia and Singapore, none of these were observed in our study (Ng et al. 2022).