HHLA2 and neoplasm: Multivariate analysis revealed that high CCL17-T maintained its prognostic significance for predicting both RFS [HR 1.774(1.274–2.470), P = 0.001] and OS [HR 1.818 (1.242–2.661), P = 0.002], along with tumor size, MVI, Treg/CD8, CCR4-T, HHLA-2-T, CD73-T, and CCR4 + CD73 + cells (Table 3).