Among other DE genes, we could highlight the differential modulation of CCND2, TJAP, GAB1, and CCR7 [15, 17], the up-regulation in PF of CD27 and CLECL1, two genes recently associated with the CLL proliferative phenotype [44, 45] as well as of MS4A1/CD20 [8] (Fig. S7C). The gene discussed is MS4A1; the disease is B-cell chronic lymphocytic leukemia.