Among these, the top 10 signaling pathways are Pathways in cancer, Lipid and atherosclerosis, Proteoglycans in cancer, Chemical carcinogenesis—receptor activation, Toxoplasmosis, TNF signaling pathway, Apoptosis, Human T-cell leukemia virus 1 infection, Ras signaling pathway, and IL-17 signaling pathway. The gene discussed is TNF; the disease is atherosclerosis.