In BMI-stratified analyses, high CRP was associated with elevated risk of events in normal-weight and overweight (HRadj:1.70 [95% CI = 1.09–2.66]; HRadj:1.75 [95% CI = 1.08–2.86]), but in obesity, the estimate was less precise (HRadj:1.73 [95% CI = 0.78–3.83]). Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.