Comparing our results with Ruan et al. is problematic since a BMI \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\ge$$\end{document}≥ 24 kg/m2 includes both normal-weight, overweight, and obesity, and they used CRP as a binary exposure 20. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.