The most likely explanations for this findings are: (1) Either the imbalance between TF/TFPI specifically affects cardiac dysfunction, (2) that troponin T is the most sensitive marker of organ dysfunction or (3) that the ratio of TF/TFPI in blood is not an appropriate indicator of coagulation activation or no relevant determinant of other organ dysfunctions in septic shock. This evidence concerns the gene TF and Shock.