On the contrary, recently, starting with epidemiological reports for lower COVID-19 incidence in populations living at high altitudes, a few studies supporting the epidemiological reports interestingly showed that an association of the rs11549465 variant of HIF1-α with COVID-19 susceptibility was recently discovered58 and hypoxic and pharmaco-logical drug of HIF inhibit the infection of lung cells by SARS-CoV-2 by reducing ACE2 viral receptor expression59. This evidence concerns the gene HIF1A and COVID-19.