Correspondingly, NLRP3+/+-neutrophil-transfused mice demonstrated significantly reduced LV functions at 12 h after MI when compared to NLRP3−/−-neutrophil-transfused mice (30.8 ± 2.6% vs. 40.8 ± 1.5% EF; n = 7; p = 0.006) (Fig. 2E, F). This evidence concerns the gene NLRP3 and myocardial infarction.