In line with the reduced infarct size, the NLRP3−/− hearts had a preserved left ventricular (LV) systolic function post-MI, as determined by echocardiography, with better LV ejection fraction (42.3 ± 1.9% vs. 26.1 ± 2.1%; p = 0.009) and fractional shortening (FS) than the NLRP3+/+ hearts (32.1 ± 2.2% vs. 19.9 ± 2.0%; p = 0.009). This evidence concerns the gene NLRP3 and myocardial infarction.