Further research is warranted to explore how other specific pathways implicated in PF pathogenesis, such as the PI3K/Akt signaling pathway, WNT/β-catenin signaling pathway, JAK/STAT signaling pathway, and AMPK signaling pathway, interact with ferroptosis in regulating the development of PF. The gene discussed is AKT1; the disease is pemphigus foliaceus.