VIM and skin squamous cell carcinoma: Finally, we characterized the presence of epithelial, hybrid E/M, and mesenchymal cancer cells by analyzing the expression of E-cadherin (Ecad, epithelial marker) and Vimentin (Vim, mesenchymal marker) in a subset of cSCC patient samples with different histopathological grades (G2-grade including MD-SCCs; G3-grade including MD/PD-SCCs and PD-SCCs; G4-grade including PD/S-SCCs) (Fig. 1g–k).