M2-like macrophages from mesenchymal cSCCs showed a marked immunosuppressive signature characterized by an increased expression of immunosuppressive molecules (Fizz1, Tgfb, Il10, Nos2, Arg1, and Gas6), the pro-angiogenic factor Vegfa, and one Treg cell-attracting cytokine as Ccl22 (Supplementary Fig. 1y), all of which may facilitate tumor progression39,40. This evidence concerns the gene NOS2 and neoplasm.