We observed that WD-SCCs were formed of epithelial α6-integrin+EpCAM+ cancer cells, MD/PD-SCCs contained a mixture of epithelial α6-integrin+EpCAM+ and mesenchymal α6-integrin+EpCAM− cancer cells, and PD/S-SCCs contained only mesenchymal α6-integrin+EpCAM− cancer cells (Fig. 1a). This evidence concerns the gene EPCAM and Menkes disease.