Since these hybrid E/M cancer cells with different degrees of expression of epithelial (e.g., EpCAM, E-cadherin) and mesenchymal (e.g., Vimentin) markers are more prone to progress to the mesenchymal state during mouse cSCC growth, their presence could be a risk factor for the increased relapse and metastasis observed in patients with advanced/high-risk cSCCs. Here, EPCAM is linked to cancer.