To further illustrate that VHL hinders the oncogenic potential of breast cancer cells through its regulation of UBE3B, we depleted UBE3B in MDA-MB-231 and T47D cells following VHL ablation (referred to as VHL-KD#1+UBE3B-KD) (Fig. 3G; Fig. S3E). This evidence concerns the gene VHL and breast carcinoma.