Approximately 90% of breast cancer-related deaths are attributed to metastasis and the lung is one of the most common metastatic sites for breast cancer [32, 33], and UBE3B regulates VEGFA expression and breast cancer lung metastasis [7], we therefore investigated whether VHL controls spontaneous breast cancer metastasis to the lungs via UBE3B. Here, UBE3B is linked to breast cancer.