Along with LSD1 impacting the CNS, KDM5C/SMCX/Jarid1c, a H3K4me2/3 demethylase, has been linked to intellectual disabilities, autism, and Huntington's disease (Fig. 4; Lan et al. 2007a; Vashishtha et al. 2013; Vallianatos and Iwase 2015; Iwase et al. 2016; Vallianatos et al. 2018). Here, KDM5C is linked to Huntington disease.