To examine the impact of HPA axis hyperexcitability on epilepsy, we used a mouse model that exhibits exacerbated seizure-induced activation of the HPA axis (Kcc2/Crh KO mice) and evaluated the impact on several epilepsy outcome measures, including spontaneous recurrent seizure frequency, characteristic neuropathological features, and psychiatric comorbidities. The gene discussed is SLC12A5; the disease is epilepsy.