CD4 and cancer: In Cluster B, there was a notable decrease in key phases of this cycle, including Cancer cell antigens are released (Step 1), and immune cells such as CD4 and CD8 T cells, macrophages, NK cells, Th1, Th2, and Th22 cells are mobilized (Step 4), along with their infiltration into the tumor (Step 5), as depicted in Figure 4B.