Figure 2D displays the genomic locations of CNVs in mitophagy-related genes. Notably, in HNSCC, genes such as TOMM7, TOMM70, MTERF3, and MFN1 have a higher frequency of CNV amplification, while SQSTM1, VDAC1, and ATG12 have a higher frequency of CNV deletion (Figure 2E). Furthermore, we delved into the mutation status of mitophagy-related genes and found that these genes have a higher mutation frequency in UCEC, COAD, SKCM, STAD, BLCA, LUSC, and LUAD, but mutations are rare in PCPG, MESO, and KICH (Figure 2F). This evidence concerns the gene VDAC1 and head and neck squamous cell carcinoma.