MFN1 and head and neck squamous cell carcinoma: Figure 2D displays the genomic locations of CNVs in mitophagy-related genes. Notably, in HNSCC, genes such as TOMM7, TOMM70, MTERF3, and MFN1 have a higher frequency of CNV amplification, while SQSTM1, VDAC1, and ATG12 have a higher frequency of CNV deletion (Figure 2E). Furthermore, we delved into the mutation status of mitophagy-related genes and found that these genes have a higher mutation frequency in UCEC, COAD, SKCM, STAD, BLCA, LUSC, and LUAD, but mutations are rare in PCPG, MESO, and KICH (Figure 2F).