Furthermore, our study revealed the connection between gene expression profiles and patient prognosis (Supplementary Figure 1C), finding that most MRGs act as risk factors in HNSC, LIHC, KICH, LUAD, LUSC, BRCA, while TOMM6 serves as a protective factor in THYM, OV, DLBC, and PINK1 as a protective factor in KIRC, KIRP, ACC. The gene discussed is PINK1; the disease is adrenal cortex carcinoma.