As reported, inhibition of certain signaling pathways can ameliorate bleomycin-induced pulmonary fibrosis, such as NF-κB/NLRP3 signaling-mediated inflammation [13], the IL-1β/IL-1R1/MyD88/NF-κB axis [14], and IL-6/STAT3 pathway [15]. Here, IL1B is linked to pulmonary fibrosis.