Based on the data from comprehensive analysis using the integrated drug target prediction; GO and KEGG pathway enrichment; and the target-pathway network, we speculated that IL-6, AKT1, TNF, IL-1β, STAT3, MMP-9, and TGF-β1 might be the key targets, which play critical roles in the inhibitory effects of QFHXD on the progression and exacerbation of PF. Here, IL1B is linked to pemphigus foliaceus.