Based on the data from comprehensive analysis using the integrated drug target prediction; GO and KEGG pathway enrichment; and the target-pathway network, we speculated that IL-6, AKT1, TNF, IL-1β, STAT3, MMP-9, and TGF-β1 might be the key targets, which play critical roles in the inhibitory effects of QFHXD on the progression and exacerbation of PF. This evidence concerns the gene TNF and pemphigus foliaceus.