We found that IGF-1 SDS shows a positive correlation with peak GH at ITT and GST both in the entire cohort and in subgroups, and the analysis of ROC curves demonstrated the best diagnostic accuracy for a cutoff IGF-1 of −1.4 SDS in both the entire cohort and in the OM-GHD group, with sensitivity and specificity ranging from 75% to 80% and 90% to 94%, respectively. This evidence concerns the gene GH1 and ocular melanoma.