The latter had a high pretest probability of permanent GHD secondary to acute lymphoblastic leukemia and TBI, central hypothyroidism, and peak GH of 1.1 μg/L at ITT and 8.72 μg/L at GST, with an IGF-I value of −2.32 SDS (Table 5). The gene discussed is GH1; the disease is Central hypothyroidism.