TLB was revealed to play a neuroprotective role in a rat model cerebral ischemia/reperfusion injury by inhibiting inflammatory and oxidative responses via the TLR4/NF-κB and Nrf2/Keap-1 pathways [29], and promoting the proliferation of cerebral microvascular endothelial cells and angiogenesis via the SIRT7/VEGFA pathway [30]. Here, KEAP1 is linked to Cerebral ischemia.