In studies of a mouse model of AD, TLB showed anti-inflammatory effects by targeting HMGB1 and regulating the Sirt3/SOD2 pathway [31], and reducing the expression levels of TNF-α, IL-1β, and IL-6 via TLR4/MYD88/NF-κB pathway [32]. The gene discussed is HMGB1; the disease is Alzheimer disease.