SPTB and preterm premature rupture of the membranes: This study represents the largest (N = 739 women, n = 2819 samples) and most comprehensive (31 immune mediators) profiling of the soluble immune response in vaginal fluid throughout well-characterized pregnancies that culminated in the delivery of a term neonate (controls) or those that resulted in sPTB (sPTL and PPROM cases) (Figure 1A).