IL1B and preterm premature rupture of the membranes: When considering the vaginal concentrations of cytokines, chemokines, growth factors, and defensins without including maternal characteristics (black line), the vaginal immunoproteome has the highest potential predictive value for early PPROM <34 (area under the curve [AUC] = 0.787) (Figure 7E), with the two most informative immune mediators for the prediction of early PPROM being VEGF and IL-1β.