Regarding the dialysis technique, patients treated with convective or mixed techniques, online HDF in particular, showed significantly lower ALP serum levels than patients on diffusive dialysis, namely 189.2 IU/L (95% confidence interval [CI]: 170.0–208.5) vs 226.3 IU/L (95% CI: 210.7–241.8, p = 0.004), respectively, even after adjustment for confounding factors such as age, sex, Kt/V, Geriatric Nutritional Risk Index, vascular access, dialysis vintage, peripheral vascular disease, smoking, and calcium, phosphate and PTH serum levels. This evidence concerns the gene PTH and vascular disorder.