INS and diabetes mellitus: The only subgroup of patients in whom metabolic indices were altered when compared with controls was that comprised of women showing hyperandrogenemia by LC–MS/MS, regardless of immunoassays; these patients presented with reduced  insulin sensitivity index and HDL-cholesterol, and increased diastolic BP values and triglycerides concentrations, and were more likely to have an abnormal glucose metabolism, namely prediabetes or diabetes mellitus (Table 4).