NF1 and breast cancer: Genetic engineering has further paved the way for models recapitulating specific molecular BC subtypes and mutational signatures, and for studying the impact of specific germline or somatic mutations in tumor suppressor genes or oncogenes associated with BC [262, 270, 303, 304], such as the creation of rats with germline Nf1 mutations using CRISPR/Cas9 gene editing [270] (Fig. 5F).