Interferon dysregulation in individuals with DS is well-established and produced by trisomy of chromosome 21 which contains a cluster of four out of six interferon receptor (IFN-R) genes: IFNAR1, IFNAR2, IFNGR2, and IL10RB (Fig. 1) [102], These genes have been previously shown to have variable expression in multiple cell types in individuals with DS and can account for baseline interferon activity and intermittent “variable” interferon activity, as would be seen in an individual having increased interferon signature in the setting of having a viral illness [103]. The gene discussed is IFNAR2; the disease is Dravet syndrome.