In addition, as a member of the transient receptor potential (TRP) channel family, TRP vanilloid 1 (TRPV1), also known as the capsaicin receptor, has been reported to improve endurance capacity and energy metabolism (Luo et al., 2012), counter obesity (Baskaran et al., 2016), and intervene diabetes (Wang et al., 2012), making it a potential target protein for discovering exercise mimetics. This evidence concerns the gene TRPV1 and obesity due to melanocortin 4 receptor deficiency.