INS and Alzheimer disease: Indeed, our “Neuroenergetic Hypothesis” proposes that brain insulin resistance, glucose hypometabolism, and energy deficit are related pivotal factors that contribute to the neuronal stress involved in migraine attack chronification, and, subsequently, if they persist over time, in the prodromal stage of AD, at least in some subgroups of patients, along a pathophysiological continuum (Fig. 2).