Therefore, we measured plasma levels of pro-inflammatory factors such as IL-1β, IL-6 and TNF-α in AAA mice, and the results showed that the plasma levels of IL-1β, IL-6 and TNF-α were significantly increased in AngII+oe-ATF4 group compared with AngII+AAV-control group, while significantly decreased in AngII+sh-ATF4 group (Fig 3 A). This evidence concerns the gene ATF4 and triple-A syndrome.