Although saline-treated ATF4Lyz2KO mice showed similar histology of aorta with ATF4fl/fl mice, macrophages-specific ATF4 deficiency markedly decreased the incidence of AAA and the maximal diameters of the suprarenal abdominal aorta compared to those in ATF4fl/fl mice after AngII infusion (Fig. 5G-H). Here, ATF4 is linked to triple-A syndrome.