To conclude, we show here that naïve mice exposed concomitantly to the major risk factors for AD/dementia, which include aging in females (induced by OVX) and exposure to acquired AD risk factors induced by a high fat-sugar-salt diet, responded by dysregulation of glucose/insulin, lipid, and liver function homeostasis, and by increase in body weight with tendency of increase in blood pressure. The gene discussed is INS; the disease is dementia.