MAPT and amyloidosis: In the context of aging and exposure to the diet/risk factors, tau pathology showed a stronger responsiveness than the amyloid pathology, based on the finding that tau pathology reached a mature state (silver staining tangle staining), while the amyloid pathology (at this time point of exposing to the risk factors) - showed the early stage of amyloid pathology, by accumulation of intracellular non fibrillar β-amyloid, yet not developing fibrillar and extracellular plaques.