KDR and major depressive disorder: The increased neoangiogenesis can point to an attempt to overcome vasculopathy taking place in the OVX-Diet mice.This increase in VEGF function is in accord with the reports of pathologically signal of VEGF in AD [54-56], which may be mediated by increasing the BBB permeability, as was reported to take place in depression - with the VEGF/VEGF receptor 2 (VEGFR2) playing a crucial role [57].