PSEN1 and Mental deterioration: In particular a study demonstrated that APP/PS1 double-transgenic mice injected with pAAV-gfap:Hamp, an astrocyte-specific Hepcidin expression Adeno-Associated Virus [228], showed a reduction of cognitive decline accompanied by a moderate reduction of Aβ plaques formation, iron levels, oxidative stress, neuroinflammation and neuronal death, in the two main regions affected by the pathology, cerebral cortex and hippocampus [167].