For instance, hub genes in EXC-M3 (Fig. 5A) included AD-associated genes HSP90AA1, HSP90AB1 which have been linked to protein misfolding, chaperoning, autophagy, apoptosis, and stress response—processes central to the dysregulation of protein integrity implicated in AD pathogenesis [70-72]. The gene discussed is HSP90AA1; the disease is Alzheimer disease.