Additional astrocyte hub genes in the ETC, including NRXN1, CADM1, MACF1, MAGI2, LRP4, GJA1 and ADGRL3, have been identified as markers of a reactive astrocyte state, implicating them in amyloidosis, regulation of neuroinflammation, cellular interactions (Dai et al., 2023). This evidence concerns the gene MACF1 and amyloidosis.