Given the altered distribution of GR-binding sites and the number observed in tumor samples from high-violence neighborhoods (Fig. 3), as well as our previous finding documenting a 31% increase in lung cancer risk for individuals residing in areas with high crime (14), we hypothesized that the rewiring of the GR cistrome in response to neighborhood violent crime increases pathways associated with tumor aggressiveness. This evidence concerns the gene NR3C1 and lung cancer.