Because we observed upregulation of glucocorticoid biosynthesis in the pathway analysis of genes, specifically those amplified in samples from high-violence neighborhoods (Fig. 1C), and considering the recognized role of GR in regulating gene expression under stress conditions, we hypothesized that genes associated with the neighborhood violent crime rate may exhibit unique GR-mediated gene regulation patterns associated with a more aggressive tumor phenotype. The gene discussed is NR3C1; the disease is neoplasm.